Harnessing Biophysical Screening Methods to Effectively Interpret Drug-Target Interactions for Better Characterization
Time: 9:01 am
day: Pre-Conference Workshop Day
Details:
To carefully select the most promising drug candidates during the early discovery phase, biophysical screening methods are utilized to better understand the interaction between the small molecule drugs and RNA target. Due to the small molecular weight change which occurs when a small molecule binds to RNA it is difficult to identify which are the most robust and sensitive biophysical screens and in what combination these should be used to gain the most accurate results.
Therefore, this workshop will address:
- Identifying the best combination of biophysical screens for accurate target identification
- Delving into the screening methods which can be used for understanding which small molecules bind to RNA and have therapeutic potential
- How to reduce the need to invest heavily in different biophysical screening methods?
- Are there any new methodologies which have been developed which are more robust and reproducible?
