Next-Generation Transcriptomic Strategy to Exploit Chemical Biology in RNA Regulator Targeting
Time: 3:30 pm
day: Conference Day Two
Details:
- Utilizing transcriptome-wide methodologies, such as STAMP/eCLIP, commonly employed for identifying RNA-binding protein (RBP) binding sites, to profile RBP-RNA interactions within cells upon perturbation by small molecules
- Profiling small molecule libraries rapidly against RBPs enables the swift generation of comprehensive cellular datasets highlighting the selectivity against RNA targets and other RBPs
- Leveraging these binding profiles offers an avenue to gain deeper insights into the functional role of targeted RBPs in disease contexts
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