Strategies to Identify Disease Relevant Long Non-Coding RNA Targets & Discover Small Molecules to Modulate their Function

Time: 1:00 pm
day: Pre-Conference Workshop Day


Current efforts to modulate disease on an RNA-level with small molecules focus mainly on splice modulation. This might be partly due to the more challenging nature of other RNA species, such as long non-coding RNAs. However, given the important function of long non-coding RNAs in a plethora of disease, targeting long non-coding RNAs might be the next frontier in small moleucles targeting RNA.

This workshop will address current challenges faced in identifying suitable long non-coding RNAs as drug targets and the discovery of small molecules to modulate their function:

  • How to identify the key regions on long non-coding RNAs which are involved in the desired functional response?
  • How can CRISPR screening methods be incorporated to identify functional long non-coding RNA?
  • How to assess undesired on-target effects due to the target long non-coding RNA being involved in several pathways
  • How to tackle issues due to the low abundance of long non-coding RNA in assays development?